A Chronic Inflammatory and Progressive Disease
Heart failure based on cardiomyopathy is a chronic inflammatory disorder and occurs when the heart muscle is unable to pump enough blood through the heart to meet the body’s needs for blood and oxygen. As of today, no therapy, drug or method has been developed and made available to treat heart failure enabling patients to continue to lead a normal and mobile life.
What is Heart Failure?
Cardiomyopathy with heart failure is a chronic inflammatory disorder
It occurs when the heart muscle is unable to pump enough blood through the heart to meet the body’s needs for blood and oxygen. The heart tries to make up for this inability. First, it enlarges – enabling it to pump more blood. Second, the heart starts to pump faster to increase its output.
Consequently, heart failure usually results in an enlarged heart.
However, the body also tries to compensate for the need for blood and oxygen in other ways. The blood vessels may narrow to keep the blood pressure up (trying to compensate the heart’s loss of power) and
blood may be diverted away from less important tissues and organs.
A Dangerous Progressive Disease
Heart failure is a progressive disease, a fact that makes it more and more difficult to treat over time
While patients may be able to continue leading a stable life for a few years after the initial episode thanks to optimal medication or to an ICD (Implantable Cardiac Defibrillator) or a CRT-D (Cardiac Resynchronization Therapy) implant, once these measures are no longer effective, a heart transplantation may have to be considered.
Ventricular Assist Devices (VAD) which are very often associated with significant side effects and a statistically short life expectancy may serve at most as a «bridge to transplant», that is, if a donor heart becomes available. Heart failure, therefore, leads to highly invasive, burdensome and costly procedures and in its end stage, ultimately to death.
As of today, no therapy, drug or method has been developed and made available to treat heart failure for a patient to lead a normal and mobile life.
The Leading Cause of Death
Facts about Heart Failure
Heart failure disease are the leading cause of death globally.
Out of the 17 million premature deaths (under the age of 70) due to noncommunicable diseases in 2019, 38% were caused by CVDs.Source: who.int
An estimated 17.9 million people died from CVDs in 2019, representing 32% of all global deaths. Of these deaths, 85% were due to heart attack and stroke.Source: who.int
Since 2000, the largest increase in deaths has been for this disease, rising by more than 2 million to 8.9 million deaths in 2019.Source: who.int